IL2 gene

From NCBI Gene:

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

From UniProt:

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Covered on Genetics Home Reference:

• rheumatoid arthritis

From UniProt:

A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Cytogenetic Location: 4q26-q27, which is the long (q) arm of chromosome 4 between positions 26 and 27

Molecular Location: base pairs 122,449,479 to 122,456,495 on chromosome 4 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

• IL-2
• lymphokine
• TCGF