IL2 gene
interleukin 2
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
From UniProt:
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Related Information
Covered on Genetics Home Reference:
From UniProt:
A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Related Information
Cytogenetic Location: 4q27, which is the long (q) arm of chromosome 4 at position 27
Molecular Location: base pairs 122,449,479 to 122,456,495 on chromosome 4 (Homo sapiens Updated Annotation Release 109.20190905, GRCh38.p13) (NCBI)

Related Information
- IL-2
- lymphokine
- TCGF