IL1RN gene

interleukin 1 receptor antagonist

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]

From UniProt:

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

From NCBI Gene:

  • Microvascular complications of diabetes 4
  • Hereditary diffuse gastric cancer
  • Osteomyelitis, sterile multifocal, with periostitis and pustulosis

From UniProt:

Microvascular complications of diabetes 4 (MVCD4): Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. [MIM:612628]

Interleukin 1 receptor antagonist deficiency (DIRA): A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells. [MIM:612852]

Cytogenetic Location: 2q14.1, which is the long (q) arm of chromosome 2 at position 14.1

Molecular Location: base pairs 113,099,365 to 113,134,016 on chromosome 2 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 2q14.1, which is the long (q) arm of chromosome 2 at position 14.1
  • DIRA
  • ICIL-1RA
  • IL-1ra
  • IL-1ra3
  • IL-1RN
  • IL1F3
  • IL1RA
  • IRAP
  • MVCD4