interleukin 1 receptor accessory protein like 1
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008]
May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons.
From NCBI Gene:
- Mental retardation 21, X-linked
Mental retardation, X-linked 21 (MRX21): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. [MIM:300143]
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
- HGNC Gene Family: I-set domain containing
- HGNC Gene Family: Immunoglobulin-like domain containing
- HGNC Gene Family: Interleukin receptors
- HGNC Gene Family: TIR domain containing
- HGNC Gene Family: X-linked mental retardation
- HGNC Gene Symbol Report
- NCBI Gene