IL1RAPL1 gene

From NCBI Gene:

The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization. [provided by RefSeq, Jul 2017]

From UniProt:

From NCBI Gene:

• Mental retardation 21, X-linked

From UniProt:

Mental retardation, X-linked 21 (MRX21): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. [MIM:300143]

Cytogenetic Location: Xp21.3-p21.2, which is the short (p) arm of the X chromosome between positions 21.3 and 21.2

Molecular Location: base pairs 28,587,446 to 29,956,718 on the X chromosome (Homo sapiens Updated Annotation Release 109.20191205, GRCh38.p13) (NCBI)

• IL-1-RAPL-1
• IL-1RAPL-1
• IL1R8
• IL1RAPL
• IL1RAPL-1
• MRX10
• MRX21
• MRX34
• OPHN4
• TIGIRR-2