IL1RAPL1 gene

From NCBI Gene:

The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008]

From UniProt:

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons.

From NCBI Gene:

• Mental retardation 21, X-linked

From UniProt:

Mental retardation, X-linked 21 (MRX21): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. [MIM:300143]

Cytogenetic Location: Xp22.1-p21.3, which is the short (p) arm of the X chromosome between positions 22.1 and 21.3

Molecular Location: base pairs 28,587,564 to 29,956,350 on the X chromosome (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

• IL1R8
• IL1RAPL
• MRX10
• MRX21
• MRX34
• OPHN4
• TIGIRR-2