IL13 gene

interleukin 13

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

From UniProt:

Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Asthma, susceptibility to
  • Allergic rhinitis

From UniProt:

Allergic rhinitis (ALRH): A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. [MIM:607154]

Cytogenetic Location: 5q31, which is the long (q) arm of chromosome 5 at position 31

Molecular Location: base pairs 132,658,173 to 132,661,109 on chromosome 5 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 5q31, which is the long (q) arm of chromosome 5 at position 31
  • IL-13
  • P600