IL10RA gene

interleukin 10 receptor subunit alpha

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

From UniProt:

Receptor for IL10; binds IL10 with a high affinity.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Inflammatory bowel disease 28, autosomal recessive

From UniProt:

Inflammatory bowel disease 28 (IBD28): A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. [MIM:613148]

Cytogenetic Location: 11q23, which is the long (q) arm of chromosome 11 at position 23

Molecular Location: base pairs 117,986,391 to 118,001,483 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 11q23, which is the long (q) arm of chromosome 11 at position 23
  • CD210
  • CD210a
  • CDW210A
  • HIL-10R
  • IL-10R1
  • IL10R