IL10 gene

interleukin 10

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

From UniProt:

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

From NCBI Gene:

  • Human immunodeficiency virus type 1, susceptibility to
  • Rheumatoid arthritis
  • Graft-versus-host disease, susceptibility to

Cytogenetic Location: 1q31-q32, which is the long (q) arm of chromosome 1 between positions 31 and 32

Molecular Location: base pairs 206,767,603 to 206,772,494 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1q31-q32, which is the long (q) arm of chromosome 1 between positions 31 and 32
  • CSIF
  • GVHDS
  • IL-10
  • IL10A
  • TGIF