IKZF4 gene

IKAROS family zinc finger 4

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

From UniProt:

DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1.

Cytogenetic Location: 12q13.2, which is the long (q) arm of chromosome 12 at position 13.2

Molecular Location: base pairs 56,007,647 to 56,038,435 on chromosome 12 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 12q13.2, which is the long (q) arm of chromosome 12 at position 13.2
  • EOS
  • ZNFN1A4