IGLL1 gene

immunoglobulin lambda like polypeptide 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

From UniProt:

Critical for B-cell development.

From NCBI Gene:

  • Agammaglobulinemia 2, autosomal recessive

From UniProt:

Agammaglobulinemia 2, autosomal recessive (AGM2): A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. [MIM:613500]

Cytogenetic Location: 22q11.23, which is the long (q) arm of chromosome 22 at position 11.23

Molecular Location: base pairs 23,573,125 to 23,580,548 on chromosome 22 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 22q11.23, which is the long (q) arm of chromosome 22 at position 11.23
  • 14.1
  • AGM2
  • CD179b
  • IGL1
  • IGL5
  • IGLJ14.1
  • IGLL
  • IGO
  • IGVPB
  • VPREB2