IGF2BP2 gene

insulin like growth factor 2 mRNA binding protein 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]

From UniProt:

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.

Cytogenetic Location: 3q27.2, which is the long (q) arm of chromosome 3 at position 27.2

Molecular Location: base pairs 185,643,739 to 185,825,051 on chromosome 3 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 3q27.2, which is the long (q) arm of chromosome 3 at position 27.2
  • IMP-2
  • IMP2
  • VICKZ2