IFNG gene
interferon gamma
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
From UniProt:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Related Information
Covered on Genetics Home Reference:
From NCBI Gene:
- Aplastic anemia
- Human immunodeficiency virus type 1, susceptibility to
- Hepatitis c virus, susceptibility to
- Tuberous sclerosis 2
- Mycobacterium tuberculosis, susceptibility to
From UniProt:
Aplastic anemia (AA): A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia. [MIM:609135]
Related Information
Cytogenetic Location: 12q15, which is the long (q) arm of chromosome 12 at position 15
Molecular Location: base pairs 68,154,768 to 68,159,740 on chromosome 12 (Homo sapiens Updated Annotation Release 109.20190905, GRCh38.p13) (NCBI)

Related Information
- IFG
- IFI