IFNG gene

From NCBI Gene:

This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]

From UniProt:

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

From NCBI Gene:

• Aplastic anemia
• Human immunodeficiency virus type 1, susceptibility to
• Hepatitis c virus, susceptibility to
• Tuberous sclerosis 2
• Mycobacterium tuberculosis, susceptibility to

From UniProt:

Aplastic anemia (AA): A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia. [MIM:609135]

Cytogenetic Location: 12q14, which is the long (q) arm of chromosome 12 at position 14

Molecular Location: base pairs 68,154,770 to 68,159,741 on chromosome 12 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

• IFG
• IFI