IFNG gene

interferon gamma

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]

From UniProt:

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Aplastic anemia
  • Human immunodeficiency virus type 1, susceptibility to
  • Hepatitis c virus, susceptibility to
  • Tuberous sclerosis 2
  • Mycobacterium tuberculosis, susceptibility to

From UniProt:

Aplastic anemia (AA): A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia. [MIM:609135]

Cytogenetic Location: 12q15, which is the long (q) arm of chromosome 12 at position 15

Molecular Location: base pairs 68,154,768 to 68,159,740 on chromosome 12 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 12q15, which is the long (q) arm of chromosome 12 at position 15
  • IFG
  • IFI
  • IMD69