IFNAR2 gene

interferon alpha and beta receptor subunit 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

From UniProt:

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).

From NCBI Gene:

  • Immunodeficiency 45
  • Hepatitis b virus, susceptibility to

From UniProt:

Immunodeficiency 45 (IMD45): An autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination. [MIM:616669]

Cytogenetic Location: 21q22.11, which is the long (q) arm of chromosome 21 at position 22.11

Molecular Location: base pairs 33,229,895 to 33,264,513 on chromosome 21 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 21q22.11, which is the long (q) arm of chromosome 21 at position 22.11
  • IFN-alpha-REC
  • IFN-R
  • IFNABR
  • IFNARB
  • IMD45