intercellular adhesion molecule 1
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.
(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
- HGNC Gene Family: CD molecules
- HGNC Gene Family: Endogenous ligands
- HGNC Gene Family: Ig-like cell adhesion molecule family
- HGNC Gene Family: Immunoglobulin like domain containing
- HGNC Gene Symbol Report
- Monarch Initiative
- NCBI Gene