HOXA11

homeobox A11

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]

From UniProt:

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

From NCBI Gene:

  • Radioulnar synostosis with amegakaryocytic thrombocytopenia

From UniProt:

Radioulnar synostosis with amegakaryocytic thrombocytopenia 1 (RUSAT1): The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. [MIM:605432]

Cytogenetic Location: 7p15.2, which is the short (p) arm of chromosome 7 at position 15.2

Molecular Location: base pairs 27,181,157 to 27,185,216 on chromosome 7 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 7p15.2, which is the short (p) arm of chromosome 7 at position 15.2
  • HOX1
  • HOX1I
  • RUSAT1