HNMT gene

histamine N-methyltransferase

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

From UniProt:

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.

From NCBI Gene:

  • Asthma, susceptibility to
  • Mental retardation, autosomal recessive 51

From UniProt:

Mental retardation, autosomal recessive 51 (MRT51): A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. [MIM:616739]

Cytogenetic Location: 2q22.1, which is the long (q) arm of chromosome 2 at position 22.1

Molecular Location: base pairs 137,964,068 to 138,016,364 on chromosome 2 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 2q22.1, which is the long (q) arm of chromosome 2 at position 22.1
  • HMT
  • HNMT-S1
  • HNMT-S2
  • MRT51