HMGA1 gene

high mobility group AT-hook 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]

From UniProt:

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

From NCBI Gene:

  • Diabetes mellitus type 2

From UniProt:

A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B.

Cytogenetic Location: 6p21, which is the short (p) arm of chromosome 6 at position 21

Molecular Location: base pairs 34,236,800 to 34,246,231 on chromosome 6 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 6p21, which is the short (p) arm of chromosome 6 at position 21
  • HMG-R
  • HMGA1A
  • HMGIY