HFM1 gene

HFM1, ATP dependent DNA helicase homolog

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is thought to be an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. Defects in this gene are a cause of premature ovarian failure 9 (POF9). [provided by RefSeq, Apr 2014]

From UniProt:

Required for crossover formation and complete synapsis of homologous chromosomes during meiosis.

From NCBI Gene:

  • Premature ovarian failure 9

From UniProt:

Premature ovarian failure 9 (POF9): An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. [MIM:615724]

Cytogenetic Location: 1p22.2, which is the short (p) arm of chromosome 1 at position 22.2

Molecular Location: base pairs 91,260,766 to 91,408,008 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1p22.2, which is the short (p) arm of chromosome 1 at position 22.2
  • helicase
  • MER3
  • POF9
  • SEC63D1
  • Si-11
  • Si-11-6