HCN1 gene

hyperpolarization activated cyclic nucleotide gated potassium channel 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]

From UniProt:

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.

From NCBI Gene:

  • Epileptic encephalopathy, early infantile, 24

From UniProt:

Epileptic encephalopathy, early infantile, 24 (EIEE24): A disease characterized by early-onset seizures, intellectual disability of varying degrees, and behavioral disturbances or autistic features in most individuals. [MIM:615871]

Cytogenetic Location: 5p12, which is the short (p) arm of chromosome 5 at position 12

Molecular Location: base pairs 45,254,950 to 45,696,118 on chromosome 5 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 5p12, which is the short (p) arm of chromosome 5 at position 12
  • BCNG-1
  • BCNG1
  • EIEE24
  • HAC-2