HCN1 gene

hyperpolarization activated cyclic nucleotide gated potassium channel 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]

From UniProt:

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.

From NCBI Gene:

  • Epileptic encephalopathy, early infantile, 24

From UniProt:

Epileptic encephalopathy, early infantile, 24 (EIEE24): A disease characterized by early-onset seizures, intellectual disability of varying degrees, and behavioral disturbances or autistic features in most individuals. [MIM:615871]

Cytogenetic Location: 5p12, which is the short (p) arm of chromosome 5 at position 12

Molecular Location: base pairs 45,254,950 to 45,696,118 on chromosome 5 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 5p12, which is the short (p) arm of chromosome 5 at position 12
  • BCNG-1
  • BCNG1
  • EIEE24
  • HAC-2