HBG1 gene

hemoglobin subunit gamma 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]

From UniProt:

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

From NCBI Gene:

  • Fetal hemoglobin quantitative trait locus 1

Cytogenetic Location: 11p15.4, which is the short (p) arm of chromosome 11 at position 15.4

Molecular Location: base pairs 5,248,272 to 5,249,857 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 11p15.4, which is the short (p) arm of chromosome 11 at position 15.4
  • HBG-T2
  • HBGA
  • HBGR
  • HSGGL1
  • PRO2979