H1-4 gene

H1.4 linker histone, cluster member

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

From UniProt:

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

From NCBI Gene:


From UniProt:

Rahman syndrome (RMNS): An autosomal dominant syndrome characterized by intellectual disability and overgrowth manifesting as increased birth length, height, weight, and/or head circumference. [MIM:617537]

Cytogenetic Location: 6p22.2, which is the short (p) arm of chromosome 6 at position 22.2

Molecular Location: base pairs 26,156,329 to 26,157,115 on chromosome 6 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 6p22.2, which is the short (p) arm of chromosome 6 at position 22.2
  • dJ221C16.5
  • H1.4
  • H1E
  • H1F4
  • H1s-4
  • HIST1H1E
  • RMNS