GYPC gene

glycophorin C (Gerbich blood group)

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

From UniProt:

This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.

From NCBI Gene:

  • Blood group, Gerbich system
  • Susceptibility to malaria

Cytogenetic Location: 2q14.3, which is the long (q) arm of chromosome 2 at position 14.3

Molecular Location: base pairs 126,655,935 to 126,696,675 on chromosome 2 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 2q14.3, which is the long (q) arm of chromosome 2 at position 14.3
  • CD236
  • CD236R
  • GE
  • GPC
  • GPD
  • GYPD
  • PAS-2
  • PAS-2'