GYPB gene

glycophorin B (MNS blood group)

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

From UniProt:

This protein is a minor sialoglycoprotein in erythrocyte membranes.

Cytogenetic Location: 4q31.21, which is the long (q) arm of chromosome 4 at position 31.21

Molecular Location: base pairs 143,995,172 to 144,021,860 on chromosome 4 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 4q31.21, which is the long (q) arm of chromosome 4 at position 31.21
  • CD235b
  • GPB
  • GYP
  • MNS
  • PAS-3
  • SS