GRXCR1 gene

glutaredoxin and cysteine rich domain containing 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells. [provided by RefSeq, Sep 2010]

From UniProt:

May play a role in actin filament architecture in developing stereocilia of sensory cells.

Covered on Genetics Home Reference:

From NCBI Gene:

  • Deafness, autosomal recessive 25

From UniProt:

Deafness, autosomal recessive, 25 (DFNB25): A form of non-syndromic sensorineural deafness characterized by moderate to severe or profound hearing loss which is progressive in some individuals but not in others. Speech development is impaired in some but not all affected individuals, and vestibular dysfunction is observed in some affected individuals. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. [MIM:613285]

Cytogenetic Location: 4p13, which is the short (p) arm of chromosome 4 at position 13

Molecular Location: base pairs 42,893,266 to 43,030,658 on chromosome 4 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 4p13, which is the short (p) arm of chromosome 4 at position 13
  • DFNB25
  • PPP1R88