GRK1 gene
G protein-coupled receptor kinase 1
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]
From UniProt:
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.
Related Information
From NCBI Gene:
- Oguchi disease 2
From UniProt:
Night blindness, congenital stationary, Oguchi type 2 (CSNBO2): A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation. [MIM:613411]
Related Information
Cytogenetic Location: 13q34, which is the long (q) arm of chromosome 13 at position 34
Molecular Location: base pairs 113,645,771 to 113,735,664 on chromosome 13 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Related Information
- GPRK1
- RHOK
- RK