GRK1 gene

G protein-coupled receptor kinase 1

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The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]

From UniProt:

Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).

Related Information

From NCBI Gene:

  • Oguchi disease 2

From UniProt:

Night blindness, congenital stationary, Oguchi type 2 (CSNBO2): A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation. [MIM:613411]

Related Information

Cytogenetic Location: 13q34, which is the long (q) arm of chromosome 13 at position 34

Molecular Location: base pairs 113,645,771 to 113,737,736 on chromosome 13 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Cytogenetic Location: 13q34, which is the long (q) arm of chromosome 13 at position 34
Credit: Genome Decoration Page/NCBI

Related Information

  • GPRK1
  • RHOK
  • RK

Related Information