GREM2 gene

gremlin 2, DAN family BMP antagonist

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]

From UniProt:

Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.

Cytogenetic Location: 1q43, which is the long (q) arm of chromosome 1 at position 43

Molecular Location: base pairs 240,489,573 to 240,612,372 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1q43, which is the long (q) arm of chromosome 1 at position 43
  • CKTSF1B2
  • DAND3
  • PRDC
  • STHAG9