GPR88 gene

G protein-coupled receptor 88

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017]

From UniProt:

Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.

From NCBI Gene:

  • Chorea, childhood-onset, with psychomotor retardation

From UniProt:

Chorea, childhood-onset, with psychomotor retardation (COCPMR): An autosomal recessive neurodevelopmental disorder characterized by abnormal involuntary movements, marked speech delay, intellectual disability and learning difficulties. [MIM:616939]

Cytogenetic Location: 1p21.2, which is the short (p) arm of chromosome 1 at position 21.2

Molecular Location: base pairs 100,538,172 to 100,542,027 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1p21.2, which is the short (p) arm of chromosome 1 at position 21.2
  • COCPMR
  • STRG