GPR68 gene

G protein-coupled receptor 68

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. [provided by RefSeq, Feb 2017]

From UniProt:

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer.

From NCBI Gene:

  • Amelogenesis imperfecta, hypomaturation type IIA6

From UniProt:

Amelogenesis imperfecta, hypomaturation type, 2A6 (AI2A6): A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. [MIM:617217]

Cytogenetic Location: 14q32.11, which is the long (q) arm of chromosome 14 at position 32.11

Molecular Location: base pairs 91,232,532 to 91,264,581 on chromosome 14 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 14q32.11, which is the long (q) arm of chromosome 14 at position 32.11
  • AI2A6
  • GPR12A
  • OGR1