GOT1 gene

glutamic-oxaloacetic transaminase 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]

From UniProt:

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

From NCBI Gene:

  • Aspartate aminotransferase, serum level of, quantitative trait locus 1

Cytogenetic Location: 10q24.2, which is the long (q) arm of chromosome 10 at position 24.2

Molecular Location: base pairs 99,396,870 to 99,430,773 on chromosome 10 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 10q24.2, which is the long (q) arm of chromosome 10 at position 24.2
  • AST1
  • ASTQTL1
  • cAspAT
  • cCAT
  • GIG18