GLS gene

glutaminase

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

From UniProt:

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.

Cytogenetic Location: 2q32.2, which is the long (q) arm of chromosome 2 at position 32.2

Molecular Location: base pairs 190,880,821 to 190,965,552 on chromosome 2 (Homo sapiens Updated Annotation Release 109.20190607, GRCh38.p13) (NCBI)

Cytogenetic Location: 2q32.2, which is the long (q) arm of chromosome 2 at position 32.2
  • AAD20
  • CASGID
  • EIEE71
  • GAC
  • GAM
  • GDPAG
  • GLS1
  • KGA