GIF gene

gastric intrinsic factor

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008]

From UniProt:

Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis.

From NCBI Gene:

  • Intrinsic factor deficiency

From UniProt:

Hereditary intrinsic factor deficiency (IFD): Autosomal recessive disorder characterized by megaloblastic anemia. [MIM:261000]

Cytogenetic Location: 11q12.1, which is the long (q) arm of chromosome 11 at position 12.1

Molecular Location: base pairs 59,829,268 to 59,845,529 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 11q12.1, which is the long (q) arm of chromosome 11 at position 12.1
  • IF
  • IFMH
  • INF
  • TCN3