GCSH gene
glycine cleavage system protein H
The information on this page was automatically extracted from online scientific databases.
From NCBI Gene:
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.[provided by RefSeq, Jan 2010]
From UniProt:
The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
Related Information
Cytogenetic Location: 16q23.2, which is the long (q) arm of chromosome 16 at position 23.2
Molecular Location: base pairs 81,081,947 to 81,096,375 on chromosome 16 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Related Information
- GCE
- NKH