GCLM gene

glutamate-cysteine ligase modifier subunit

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Cytogenetic Location: 1p22.1, which is the short (p) arm of chromosome 1 at position 22.1

Molecular Location: base pairs 93,885,199 to 93,909,598 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1p22.1, which is the short (p) arm of chromosome 1 at position 22.1