FXYD2 gene

FXYD domain containing ion transport regulator 2

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]

From UniProt:

May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.

From NCBI Gene:

  • Hypomagnesemia 2, renal

From UniProt:

Hypomagnesemia 2 (HOMG2): A disorder due to primary renal wasting of magnesium. Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is lowered renal excretion of calcium resulting in hypocalciuria. [MIM:154020]

Cytogenetic Location: 11q23, which is the long (q) arm of chromosome 11 at position 23

Molecular Location: base pairs 117,820,075 to 117,828,092 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 11q23, which is the long (q) arm of chromosome 11 at position 23
  • ATP1G1
  • HOMG2