FUT8 gene

fucosyltransferase 8

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

From UniProt:

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.

From NCBI Gene:

  • CONGENITAL DISORDER OF GLYCOSYLATION WITH DEFECTIVE FUCOSYLATION

Cytogenetic Location: 14q23.3, which is the long (q) arm of chromosome 14 at position 23.3

Molecular Location: base pairs 65,410,592 to 65,744,122 on chromosome 14 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 14q23.3, which is the long (q) arm of chromosome 14 at position 23.3