FUT1 gene

fucosyltransferase 1 (H blood group)

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Aug 2016]

From UniProt:

Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.

Cytogenetic Location: 19q13.3, which is the long (q) arm of chromosome 19 at position 13.3

Molecular Location: base pairs 48,747,826 to 48,755,390 on chromosome 19 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 19q13.3, which is the long (q) arm of chromosome 19 at position 13.3
  • H
  • HH
  • HSC