FSHB gene

follicle stimulating hormone subunit beta

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

From UniProt:

Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432).

Covered on Genetics Home Reference:

From NCBI Gene:

  • Follicle-stimulating hormone deficiency, isolated

From UniProt:

Hypogonadotropic hypogonadism 24 without anosmia (HH24): A form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH24 is characterized by primary amenorrhea in women, oligo or azoospermia with low to normal testosterone levels in men, and infertility. [MIM:229070]

Cytogenetic Location: 11p14.1, which is the short (p) arm of chromosome 11 at position 14.1

Molecular Location: base pairs 30,231,016 to 30,235,277 on chromosome 11 (Homo sapiens Annotation Release 109, GRCh38.p12) (NCBI)

Cytogenetic Location: 11p14.1, which is the short (p) arm of chromosome 11 at position 14.1