FRZB gene

frizzled-related protein

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]

From UniProt:

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

From NCBI Gene:

  • Osteoarthritis susceptibility 1

From UniProt:

Osteoarthritis 1 (OS1): A degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. [MIM:165720]

Cytogenetic Location: 2q32.1, which is the long (q) arm of chromosome 2 at position 32.1

Molecular Location: base pairs 182,833,275 to 182,866,770 on chromosome 2 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 2q32.1, which is the long (q) arm of chromosome 2 at position 32.1
  • FRE
  • FRITZ
  • FRP-3
  • FRZB-1
  • FRZB-PEN
  • FRZB1
  • FZRB
  • hFIZ
  • OS1
  • SFRP3
  • SRFP3