FOXD3 gene

forkhead box D3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]

From UniProt:

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.

From NCBI Gene:

  • Autoimmune disease 1

From UniProt:

Autoimmune disease 1 (AIS1): An autoimmune disorder characterized by the association of vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis). [MIM:607836]

Cytogenetic Location: 1p31.3, which is the short (p) arm of chromosome 1 at position 31.3

Molecular Location: base pairs 63,322,567 to 63,325,128 on chromosome 1 (Homo sapiens Updated Annotation Release 109.20191205, GRCh38.p13) (NCBI)

Cytogenetic Location: 1p31.3, which is the short (p) arm of chromosome 1 at position 31.3
  • AIS1
  • Genesis
  • HFH2
  • VAMAS2