FMO5 gene

flavin containing monooxygenase 5

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

From UniProt:

In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

Cytogenetic Location: 1q21.1, which is the long (q) arm of chromosome 1 at position 21.1

Molecular Location: base pairs 147,183,963 to 147,225,798 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1q21.1, which is the long (q) arm of chromosome 1 at position 21.1