FIGLA gene

folliculogenesis specific bHLH transcription factor

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009]

From UniProt:

Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.

From NCBI Gene:

  • Premature ovarian failure 6

From UniProt:

Premature ovarian failure 6 (POF6): An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. [MIM:612310]

Cytogenetic Location: 2p13.3, which is the short (p) arm of chromosome 2 at position 13.3

Molecular Location: base pairs 70,777,310 to 70,790,643 on chromosome 2 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 2p13.3, which is the short (p) arm of chromosome 2 at position 13.3
  • BHLHC8
  • FIGALPHA
  • POF6