FGF20 gene

fibroblast growth factor 20

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]

From UniProt:

Neurotrophic factor that regulates central nervous development and function.

From NCBI Gene:

  • Renal hypodysplasia/aplasia 2

From UniProt:

Renal hypodysplasia/aplasia 2 (RHDA2): A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy. [MIM:615721]

Cytogenetic Location: 8p22, which is the short (p) arm of chromosome 8 at position 22

Molecular Location: base pairs 16,992,825 to 17,002,165 on chromosome 8 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 8p22, which is the short (p) arm of chromosome 8 at position 22
  • FGF-20
  • RHDA2