FGF14 gene

fibroblast growth factor 14

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

From UniProt:

Probably involved in nervous system development and function.

From NCBI Gene:

  • Spinocerebellar ataxia 27

From UniProt:

Spinocerebellar ataxia 27 (SCA27): Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits. [MIM:609307]

Cytogenetic Location: 13q33.1, which is the long (q) arm of chromosome 13 at position 33.1

Molecular Location: base pairs 101,720,855 to 102,402,428 on chromosome 13 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 13q33.1, which is the long (q) arm of chromosome 13 at position 33.1
  • FGF-14
  • FHF-4
  • FHF4
  • SCA27