FFAR4 gene

free fatty acid receptor 4

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

From UniProt:

Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.

From NCBI Gene:

  • Body mass index quantitative trait locus 10

Cytogenetic Location: 10q23.33, which is the long (q) arm of chromosome 10 at position 23.33

Molecular Location: base pairs 93,566,179 to 93,590,072 on chromosome 10 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 10q23.33, which is the long (q) arm of chromosome 10 at position 23.33
  • BMIQ10
  • GPR120
  • GPR129
  • GT01
  • O3FAR1
  • PGR4