FCRL4 gene

Fc receptor like 4

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]

From UniProt:

May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.

Covered on Genetics Home Reference:

From UniProt:

A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).

A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

Cytogenetic Location: 1q21, which is the long (q) arm of chromosome 1 at position 21

Molecular Location: base pairs 157,573,749 to 157,598,080 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1q21, which is the long (q) arm of chromosome 1 at position 21
  • CD307d
  • FCRH4
  • IGFP2
  • IRTA1