FCGR3A gene

Fc fragment of IgG receptor IIIa

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

From UniProt:

Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

From NCBI Gene:

  • Immunodeficiency 20

From UniProt:

Immunodeficiency 20 (IMD20): A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV). [MIM:615707]

Cytogenetic Location: 1q23.3, which is the long (q) arm of chromosome 1 at position 23.3

Molecular Location: base pairs 161,541,759 to 161,550,623 on chromosome 1 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 1q23.3, which is the long (q) arm of chromosome 1 at position 23.3
  • CD16
  • CD16A
  • FCG3
  • FCGR3
  • FCR-10
  • IGFR3
  • IMD20