FBP1 gene

fructose-bisphosphatase 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]

From UniProt:

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

From NCBI Gene:

  • Fructose-biphosphatase deficiency

From UniProt:

Fructose-1,6-bisphosphatase deficiency (FBP1D): An autosomal recessive metabolic disorder characterized by impaired gluconeogenesis, and episodes of hypoglycemia and metabolic acidosis that can be lethal in newborn infants or young children. [MIM:229700]

Cytogenetic Location: 9q22.3, which is the long (q) arm of chromosome 9 at position 22.3

Molecular Location: base pairs 94,603,133 to 94,640,257 on chromosome 9 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 9q22.3, which is the long (q) arm of chromosome 9 at position 22.3