FAT1 gene

FAT atypical cadherin 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]

From UniProt:

Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.

Cytogenetic Location: 4q35, which is the long (q) arm of chromosome 4 at position 35

Molecular Location: base pairs 186,587,783 to 186,726,915 on chromosome 4 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 4q35, which is the long (q) arm of chromosome 4 at position 35
  • CDHF7
  • CDHR8
  • FAT
  • hFat1
  • ME5