F11 gene

coagulation factor XI

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

From UniProt:

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

From NCBI Gene:

  • Hereditary factor XI deficiency disease

From UniProt:

Factor XI deficiency (FA11D): A hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. [MIM:612416]

Cytogenetic Location: 4q35.2, which is the long (q) arm of chromosome 4 at position 35.2

Molecular Location: base pairs 186,265,945 to 186,290,727 on chromosome 4 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 4q35.2, which is the long (q) arm of chromosome 4 at position 35.2