ENTPD1 gene

ectonucleoside triphosphate diphosphohydrolase 1

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

From UniProt:

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

From NCBI Gene:

  • Spastic paraplegia 64, autosomal recessive

From UniProt:

Spastic paraplegia 64, autosomal recessive (SPG64): A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. [MIM:615683]

Cytogenetic Location: 10q24.1, which is the long (q) arm of chromosome 10 at position 24.1

Molecular Location: base pairs 95,710,901 to 95,877,266 on chromosome 10 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 10q24.1, which is the long (q) arm of chromosome 10 at position 24.1
  • ATPDase
  • CD39
  • NTPDase-1
  • SPG64