EI24 gene

EI24, autophagy associated transmembrane protein

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]

From UniProt:

Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy.

From UniProt:

EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.

Cytogenetic Location: 11q24, which is the long (q) arm of chromosome 11 at position 24

Molecular Location: base pairs 125,569,216 to 125,584,689 on chromosome 11 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 11q24, which is the long (q) arm of chromosome 11 at position 24
  • EPG4
  • PIG8
  • TP53I8