EBF3 gene

early B-cell factor 3

The information on this page was automatically extracted from online scientific databases.

From NCBI Gene:

This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011]

From UniProt:

Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.

From NCBI Gene:

  • HYPOTONIA, ATAXIA, AND DELAYED DEVELOPMENT SYNDROME

Cytogenetic Location: 10q26.3, which is the long (q) arm of chromosome 10 at position 26.3

Molecular Location: base pairs 129,835,232 to 129,964,274 on chromosome 10 (Homo sapiens Annotation Release 108, GRCh38.p7) (NCBI)

Cytogenetic Location: 10q26.3, which is the long (q) arm of chromosome 10 at position 26.3
  • COE3
  • EBF-3
  • HADDS
  • O/E-2
  • OE-2